Impurity
EMA has made this aspect of the review a priority and will update the public as soon as new information becomes available. EMA will consult toxicology experts to better understand the impact that use of medicines containing the NDMA impurity may have on patients.
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The review will also seek to establish how long and at what levels patients might have been exposed to NDMA. NDMA is an unexpected impurity that was not detected by routine tests carried out by Zhejiang Huahai. EMA is now gathering details of the company's manufacturing processes, following changes introduced in that are believed to have produced NDMA as a side product.
EMA is also working closely with national authorities to evaluate whether other medicines containing valsartan other than those being recalled could also contain the same impurity. Further information about the review of valsartan, including the questions being addressed to companies, is available on EMA's website.
Q3A - Q3D Impurities
Valsartan is an angiotensin-II-receptor antagonist used to treat hypertension high blood pressure , recent heart attack and heart failure. It is available on its own or in combination with other active substances. The review covers all medicines that contain valsartan supplied by Zhejiang Huahai Pharmaceuticals.
As a precaution, the review will also consider whether other valsartan medicines may be affected. The review is being carried out by the Committee for Medicinal Products for Human Use CHMP , responsible for questions concerning medicines for human use, which will adopt the Agency's opinion. The solitons of two neighboring occupied sites are mapped to two neighboring up spins. Instead of lattice sites, the system can be represented as bonds.
The bonds are either empty or occupied by a spinless fermion, corresponding to a domain wall in the spin chain. Panels a and b correspond to the MI and panels c and d to the incommensurate phase. Density distribution of the bath fermions and the impurity in a the commensurate and b the incommensurate phase.
Panels e and f show the antisoliton distribution for incommensurate filling. Density of particles in a harmonic trap, in the ground state of Hamiltonian D1.
Impurity in buffer substances mimics the effects of ATP on soluble 5'-nucleotidase.
The height of the potential at the edges of the lattice is 4. Antisoliton distributions as in Figs. At commensurate filling, the distribution is not significantly modified from the case of a uniform potential, whereas at incommensurate filling, the antisoliton is confined closer to the center of the lattice.
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Impurity and soliton dynamics in a Fermi gas with nearest-neighbor interactions A. A 95 , — Published 7 June Abstract We study spinless fermions with repulsive nearest-neighbor interactions perturbed by an impurity particle or a local potential quench.
Weyl fermions are observed in a solid. Figure 1 a Model: Figure 4 a Number of antisolitons N AS as a function of time for both perturbations and initial states.
Condensed Matter > Quantum Gases
Figure 5 Spinless fermions with nearest-neighbor interactions off half filling can be mapped to an X X Z chain with a nonzero magnetization. Figure 6 Indexing of the lattice sites and bonds of the spin model. Figure 7 Instead of lattice sites, the system can be represented as bonds. Figure 9 Upper panel:
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