ARVO 2010 Abstracts - Glaucoma

Identification of an enhancer that regulates Otx2 expression during early retinal differentiation Open Access. Cell cycle gene reactivation in rd1 mouse retina prior to degeneration Open Access. Retinoic acid engineered amniotic membrane used as a graft or homogenates: Sphingolipids in the Human Cornea, to boldly go where no one has gone before Open Access. Novel approaches to anchoring therapeutic factors to corneal stroma to promote wound healing.

Evaluating the effect of hyaluronic acid-containing artificial tear products on corneal wound re-epithelialization in an in vivo preclinical study. Effect of ST, an amnion-derived multipotent progenitor cell-derived secretome, in a corneal incision model for post-operative inflammation Open Access. Alginate-encapsulated adipose-derived stem cells: Semaphorin3A is an inducer of neuronal growth and nerve regeneration in adult corneas.

Transparency of suture able, nanofiber reinforced, alginate hydrogels for corneal wound healing Open Access. Expression in the cornea and its role in corneal wound healing Open Access. The effect of human growth hormone on corneal wound healing in mice Open Access. Growth of human corneal epithelial cell on silk films with different nanotopographies. Optimized gene therapy normalizes wound healing and stem cell marker expression in cultured diabetic limbal epithelial cells. Effect of conditioned medium on corneal epithelial cells wound healing in vitro Open Access.

Influence of the molecular weight on the suture retention properties of polycaprolactone Open Access. Mice gender and strain affect neurotrophin secretion and corneal nerve regeneration after injury Open Access. Potential role of topical bovine colostrum in remodeling corneal epithelial cells after an acute ocular alkali burn in mice Open Access. Corneal Keratocytes Open Access. Corneal wound healing mechanisms modulated by novel antimicrobial peptides Open Access. Anne Kasus-Jacobi; Amanda J.

Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal wound healing Open Access. An ex vivo model using porcine eyeballs for wound healing studies Open Access. Corneal woundhealing model employing a bioreactor Open Access. Outcomes of multiple-dose fibrin glue during in-office pterygiectomy Open Access.

Gregory A Hutcheson; David O. Interleukin-6 expression in an ex vivo model of equine corneal wound healing Open Access. Thermal injuries of the cornea: Injury patterns and histopathology Open Access. Genetic, environmental and phenotypic risk factors for progression of age-related macular degeneration Open Access. Getting to the root of MacTel: Incidence and de-novo mutation rate of Marfan syndrome and risk of ectopia lentis Open Access.

Heritability of retinal vascular fractals: Newly identified genes for refractive error and risk of myopia Open Access. European ancestry is associated with lower risk of primary open angle glaucoma in Latinos Open Access. Genetic heritability and associations of Pigmentary Glaucoma Open Access. The Amish Eye Study: Systemic Effects of AAV. H suppresses neovascularization through inhibition of secretion of VEGF and proliferation of vascular endothelial cells Open Access.

The efficacy of aflibercept in treating retinopathy of prematurity in the mouse model of oxygen-induced retinopathy Open Access. Clay Smith; Jade Gieseke Guevara. Blockade of Apelin Receptor APJ can inhibit developmental retinal vessel outgrowth in pups and promote normal revascularization and reduce pathological neovascularization in OIR model i Therapeutic potential of topical administration of H, an isoquinoline sulfonamide derivative, in wet AMD and proliferative diabetic retinopathy Open Access.

The long leap from drug affinity to efficacy: Intervening factors that strongly influence clinical outcomes Open Access. Panobinostat reduces neovascularization in an alkali-induced corneal injury model Open Access. Anti-VEGF induced nephropathy following intravitreal administration: Effects of anti-angiogenic drugs on expression patterns of genes involved in different AMD pathogenetic pathways Open Access.

Tarek Moustafa; Shari R. Ciliary neurotrophic factor in patients with age-related cataract Open Access. Surface analytical studies of growth factor coupling to collagen by copper-free click chemistry Open Access. An increased expression of IL and Foxp3 is observed in contrast to other Th genes in primary pterygium Open Access. Quantification of aflibercept and ranibizumab efficacy in DLaminoadipic acid DLAAA -induced retinal neovascularization and vascular leakage in nonhuman primates Open Access.

Comparison of pain and comfort for intravitreal administration of anti-VEGF agents using blepharostat vs non blepharostat techniques. Increased levels of nitric oxide may pathologically affect functional hyperemia in the retina: Treatment outcomes of chronic central serous retinopathy in women compared to men Open Access. Microelectrode penetration of the wall of porcine retinal arterioles in vitro results in recordings from at least two different cell types.

Mouse retina is amenable to cholesterol lowering by a statin Open Access. Impaired retinal signal transmission in simvastatin fed mice Open Access. One year retrospective analysis of ocriplasmin for the treatment of symptomatic vitreomacular traction Open Access. Effect of exogenous carotenoids on retinal pigment epithelium cells Open Access.

Post-hypoxic recovery of the diameter of retinal arterioles is impaired in diabetic patients without retinopathy. Cost effectiveness of Intravitreal Ocriplasmin for vitreomacular adhesion and macular hole Open Access.

Past Annual Meetings

Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina Open Access. Modulation of electrical activity in the retina of the rd10 mouse model using neuroprotective drugs Open Access. Identification of a novel small molecule chaperon of rhodopsin and its therapeutic potential in retinal degeneration Open Access.

Preclinical results of a new pharmacological therapy approach for Stargardt disease and dry age-related macular degeneration Open Access. Testing a new pharmacological therapy approach for the removal of lipofuscin in vitro: Using pathway-specific reporter and direct conversion constructs to investigate Juvenile Neuronal Ceroid Lipofuscinosis.

The Joubert Syndrome cilia proteins arl13b and ahi1 differentially modify the severity of retinal degeneration due to loss of cep in zebrafish Open Access. Rod photoreceptor-specific ablation of dehydrodolichyldiphosphate synthase DHDDS causes rapid retinal degeneration: A new model for arRP Open Access. Early photoreceptor cell impairment upon AdipoR1 genetic ablation Open Access.

Past Annual Meetings

Lasting effects of prenatal marijuana exposure on the retina: The Complement System is required in maintaining retinal function Open Access. Progression of photoreceptor degeneration in a porcine model of retinitis pigmentosa Open Access. Abnormal Retinal Function Open Access.

NK-4 dye reduces the apoptosis of photoreceptor cells Open Access. Features of retinitis pigmentosa defined by high throughput sequencing and wide field imaging Open Access. Inherited retinal degeneration in the cynomolgus monkey Macaca fascicularis Open Access.

Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model Open Access. Detailed phenotypic characterization of a Beagle dog with the complete form of Schubert Bornschein congenital stationary night blindness. Time-dependent local expression pattern of complement components in light-induced photoreceptor degeneration Open Access.

The effect of light exposure in the population of different retinal neurons under taurine depletion Open Access. Intravitreal transduction profile of recombinant adeno-associated virus in murine and human retina Open Access. In vivo imaging of the choriocapillaris using adaptive optics enhanced indocyanine green ophthalmoscopy Open Access. Bille; Joseph T Fan. Examining the human retina with a compact multimodal adaptive optics line scanning ophthalmoscope Open Access.

October Woods Hole, MA. There is no specific level of elevated eye pressure that definitely leads to glaucoma; conversely, there is no lower level of IOP that will absolutely eliminate a person's risk of developing glaucoma. Where the Money Goes. Like Us on Facebook. We appreciate support from corporations who believe in our mission to educate glaucoma patients and speed a cure. Contrast Dark on Light Light on Dark. Send this article to a friend by filling out the fields below: An Innovative Research Model. High Eye Pressure and Glaucoma There is no specific level of elevated eye pressure that definitely leads to glaucoma; conversely, there is no lower level of IOP that will absolutely eliminate a person's risk of developing glaucoma.

Please enter your question in the Search box below. The open-label dose-escalating study enrolled 15 patients, and while the maximum tolerated dose was not reached, single doses up to 1. Although not powered to show significance, the results also suggested positive biological activity of iSONEP with reductions in CNV lesion size and decreases in central retinal thickness noted in some patients.

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Also noteworthy was a preclinical study evaluating the effect of the histone deacetylase HDAC inhibitors valporic acid VPA , 4-phenylbutyrate PBA and the VPA analog valpromide VPD on the survival and function of retinal pigment epithelium cells in response to oxidative stress and complement attack. VPA and VPD both increased cell viability following challenge with the oxidative agent hydroquinone and protected against complement mediated cell death in vitro.

VPA also protected against oxidative stress induced by intravitreal paraquat injection in mice, suggesting it may be a worthwhile agent for future clinical studies. Once again, there was also no shortage of exciting research on diabetic retinopathy presented this year. Much of this work focused on VEGF-inhibitors, which continue to show promising results both in monotherapy and in conjunction with laser photocoagulation. These results suggest that pegaptanib may provide an effective alternative treatment for patients for whom laser treatment is contraindicated. Beck CJ, et al. Further down the pipeline, another potential VEGF-inhibitor, erythropoietin, showed efficacy in a rat model of early diabetes.

Eyes treated with intravitreal EPO had downregulated expression of VEGF and HIF-1alpha a transcription factor involved in the cellular response to hypoxia and exhibited total retinal thickness and cell numbers similar to those of the non-diabetic controls. Several presentations at the ARVO meeting represented the continuing endeavor to better understand the risk factors and pathophysiology of dry eye. Japan's Murat Dogru, MD, and colleagues demonstrated the role of dehydration in dry eye by comparing subjects drinking a controlled amount of alcohol n: Twelve hours after alcohol intake, substantial detrimental changes were observed in tear-function metrics e.

These results suggest substantial effects of alcohol on tear function. Dogru M, et al. Research efforts to enhance the understanding of the intricate relationship between visual function, blinking and dry eye were present in abundance across different groups of scientists and clinicians. Researchers from SUNY College of Optometry demonstrated increased symptomatology following computer use compared to that reported after hard-copy fixation in a study of 24 participants.

While these findings correlated to ocular surface disease severity, there was no apparent correlation to decreased blink rate. Chu CA , et al.

CFC1 Bibliography of Publications and Abstracts | Glaucoma Research Foundation

ARVO E-abstract Our group presented results of its studies using customized video processing methodology to decipher blink patterns in dry-eye patients and normals, as well as to quantify the amount of corneal exposure which occurs between blinks in a new metric called the time-area Ocular Protection Index. White R, et al. Clinical research models and results of clinical trials of developing therapies were also presented. Our group presented exciting data using the Enhanced Controlled Adverse Environment system, which has been used in a number of clinical trials in recent years, and represents the precision possible when using honed diagnostics and clinical trial design features.

Ousler GW, et al. Hsu H-C, et al. Komuro A, et al. ARVO E-abstract Finally, another study presented results of an ophthalmic anionic lipid emulsion containing HP-Guar, demonstrating potential as a novel artificial tear. Ketelson HA, et al. In addition, a few intriguing examples of preclinical research with potential clinical application in the future emerged. Lubricin—a glycoprotein found in the cartilage of the knee—demonstrated reduced friction and tissue wear when tested using biomechanical machinery and human corneas and eyelids, which may suggest an advantage as an ocular surface lubricant.

Schmidt TA, et al.

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ARVO E-abstract One group of researchers presented intriguing results of a mouse study demonstrating the potential of both vitamin D and its active metabolite 1, OH 2D to improve corneal epithelial barrier function, which may suggest clinical applications with further research. Watsky MA, et al. Finally, prior to ARVO, expert clinical researchers, scientists, regulators, pharmaceutical executives, and venture capitalists interested in dry eye convened at the Dry Eye Summit, an event co-sponsored by our pharmaceutical consulting firm, Ora.

Topics presented ranged from the history of dry eye, to defining dry eye, to clinical regulatory and exit strategies. The summit imparted a business and regulatory spin to the discussion of innovations in dry-eye therapy. In a preclinical study, the combination of dexamethasone and povidone-iodine 0. FST reduced viral titers significantly more than placebo or Tobradex when all were applied q. Titer reductions with FST were comparable with those seen with twice daily cidofavir 0. Animals were also scored for symptoms such as conjunctival and eyelid inflammation, exudates, excessive tearing and corneal neovascularization.